Metabolism | The Krebs Cycle

This video provides a comprehensive breakdown of the Krebs cycle, detailing each step, enzyme, and regulatory mechanism. It also explores the clinical relevance of enzyme deficiencies and mutations, linking metabolic pathways to disease.

• Understand the initial steps of the Krebs cycle and its key intermediates.
• Explain the regulation of citrate synthase, the first committed step of the cycle.
• Describe the aconitase enzyme and its inhibition by fluoroacetate.
• Analyze the function and regulation of isocitrate dehydrogenase.
• Examine alpha-ketoglutarate dehydrogenase and its role in gene expression and cancer.
• Understand succinyl-CoA synthetase and ATP production via substrate-level phosphorylation.